argylesock says… My science blog isn’t usually about genetics, but I’m reblogging this post. Recently we talked about bans on using animals to test cosmetics and I agreed that the ban should be worldwide. But there’s good science going on, involving animal work. This genetic study is an example of it.
Mouse models are teaching us a lot about developmental disorders, but some mutations remain hidden because of their very nature. Tim Mohun explains how a major new genetics project is going to uncover them.
What are the functions of all the genes in our genome and which of them cause inherited disease? Answering these questions is an ambitious challenge, but one which is now becoming feasible. Already, there is a coordinated international effort making progress along this path, using the laboratory mouse as a model. The goal is to knock out each of the 20,000 genes in the mouse genome one by one and test their effect on growth, development, health and behaviour of the mouse. Production of the mutant mouse lines is underway, based in the UK at the Wellcome Trust Sanger Institute and the MRC Mary Lyon Centre at Harwell. Adults from each line are comprehensively tested to identify any effects of…
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